MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Gübitz G, Schmid MG
Article Title: Chiral separation principles in chromatographic and electromigration techniques.
Publication date: 2006
Journal: Molecular Biotechnology
Volume: 32
Issue: (2)
Page numbers: 159-179.
DOI: 10.1385/MB:32:2:159

Abstract: Almost half of the drugs in use today are chiral. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). There can be qualitative and quantitative differences in the activity of the enantiomers. In many cases, the inactive enantiomer (distomer) shows unwanted side effects or even toxic effects. Even if the side effects are not that drastic, the distomer has to be metabolized and this represents all unnecessary burden for the organism. Therefore, the development of methods for the separation of enantiomers, both on analytical and preparative scale, has become increasingly important. Chromatographic techniques such as thin layer chromatography (TLC), gas chromatography (GC), supercritical fluid chromatography (SFC), and above all high-performance liquid chromatography (HPLC) have been used for enantiomer separation for about two decades. More recently, electromigration techniques, Such as capillary electrophoresis and capillary electrochromatography, have been shown to be powerful alternatives to chromatographic methods. This review gives a short overview of different chiral separation principles and their application. Several new developments are discussed
Template and target information: Review - chiral chromatography
Author keywords: enantioseparation, chiral separation, capillary electrophoresis, capillary electrochromatography, thin layer chromatography, gas chromatography, high-performance liquid chromatography, supercritical fluid chromatography


  MIPs are Forever spoof movie poster shirt  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner