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Reference type: Journal
Authors: Potterat O, Hamburger M
Article Title: Natural products in drug discovery - Concepts and approaches for tracking bioactivity.
Publication date: 2006
Journal: Current Organic Chemistry
Volume: 10
Issue: (8)
Page numbers: 899-920.
DOI: 10.2174/138527206776894401

Abstract: Effective methods for localization and characterization of bioactivity are a cornerstone for natural product based drug discovery efforts. Over the last decade, a wealth of new technologies and conceptual approaches for bioactivity screening have emerged. These developments are reviewed under the perspective of their applicability in the field of natural products discovery. The methods discussed here include bioautography, HPLC-based activity profiling, HPLC-based on-flow bioassays, assays based on capillary electrophoresis, molecular imprinted polymers, various MS and NMR-based methods, biosensors, and chip-based technologies for affinity separation and expression profiling. Selected examples illustrate the potential and limitations of the different approaches for contemporary natural products lead discovery
Template and target information: Review - natural product drug discovery


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