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Abstract: The synthesis and evaluation of a molecularly imprinting polymeric monolith (MIPM) as an on-line selective solid-phase extraction column, for the efficient preconcentration and determination of arsanilic acid (PABAA) in water was reported. MIPM was prepared by in situ polymerization using PABAA as the template molecule, methacrylic acid as the functional monomer and ethyleneglycol dimethacrylate as the cross-linking monomer in acetonitrile and methanol solvent. The recognition mechanism and retention behavior of the MIPM were examined and subjected to a comparison to non-imprinted blank monolithic column (CP, in the absence of template) and 3-NHPAA monolithic column (3-NHPAA-MIPM, template is 3-NHPAA). The retention of PABAA on the MIPM could be reduced by increasing the ratio of water to MeOH: ACN (1:1, v/v) in eluting buffer and this solvent mixture (10ng/L of template) was used for enriching the analyte. The influence of enrichment time and flow rates was investigated and optimized. Using on-line solid-phase extraction MIPM, enrichment time of 5h and flow rates of 0.5mL/min, resulted in a nominal enrichment factor of 83. The off-line solid-phase extraction of batch extraction of PABAA from standard solutions was also investigated and resulted in a considerable enrichment of PABAA but not as nominal as on-line solid-phase extraction
Template and target information: arsanilic acid
Author keywords: Arsanilic acid, Monolithic molecular imprinted, on-line, Roxarsone