MIPdatabase
Authors: Guo HS, He XW, Jing Y, Liang H
Article Title: Studies on the binding nature in molecularly imprinted polymer selective for 4-aminopyridine.
Publication date: 2001
Journal: Chemical Journal of Chinese Universities
Volume: 22
Issue: (5)
Page numbers: 739-743.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-GDXH200105006.htm
Abstract: A molecularly imprinted polymer was prepared using 4- aminopyridine as template. The bulk polymer obtained was ground up, sieved and investigated in equilibrium binding experiments to evaluate the binding characteristics of the 4-aminopyridine- imprinted polymer. Scatchard analysis showed that two classes of binding sites were produced in the polymer matrix and their dissociation constants were calculated to be 6.0 mu mol/L and 1.2 mmol/L respectively, by utilizing the model of multiple independent classes of binding sites. The substrate selectivity of the polymer was investigated. The results showed that the imprinted polymer exhibited much higher affinity for 4- aminopyridine amongthe tested compounds. H-1 NMR studies and the analysis of the resonance structure of 4-aminopyridine indicated that the selective binding interaction between the template and binding sites in the polymer arose from their ionic interaction
Template and target information: 4-aminopyridine
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