MIPdatabase
Authors: Wolman FJ, Smolko EE, Cascone O, Grasselli M
Article Title: Peptide imprinted polymer synthesized by radiation-induced graft polymerization.
Publication date: 2006
Journal: Reactive and Functional Polymers
Volume: 66
Issue: (11)
Page numbers: 1199-1205.
DOI: 10.1016/j.reactfunctpolym.2006.03.002
Alternative URL: http://www.sciencedirect.com/science/article/B6TY0-4JRKCYD-2/2/6ba21a10c25cb06476cbe17398b444ed
Abstract: The design of polymer surfaces with molecular recognition capabilities is an exciting subject with potential application in the analytical and biotechnological fields. Molecular imprinted polymers (MIPs) are still in their infancy and new methodologies are required to broaden their application. In this paper, MIPs were synthesized by simultaneous radiation-induced graft polymerisation in a polar medium. Bacitracin, a cyclic decapeptide, was used as the target molecule to develop MIP grafted onto macroporous membranes. Soluble ternary complexes of vinyl pyridine, bacitracin and copper (II) were obtained and characterized by visible spectroscopy in an aqueous medium. These complexes were grafted onto macroporous polyethylene membranes. MIP materials showed ability to adsorb bacitracin in a higher amount than non-printed polymers. In addition, these materials showed a 5-fold greater selectivity to bacitracin than that of chemically modified bacitracins
Template and target information: Bacitracin, cyclic decapeptide
Author keywords: imprinted polymers, γ-Radiation, Bacitracin, Graft polymerisation
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