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Abstract: Molecularly imprinted polymers (MIPs) are synthetic materials capable of selective binding of a desired substrate. In their function, they mimic biological systems such as antibodies and enzymes, but due to their ease of preparation, versatility, and chemical stability, are rapidly gaining popularity as alternatives to traditional approaches for achieving molecular recognition. One of the challenges that has faced researchers in the field is that of cross-reactivity and the resulting loss of selectivity for the desired template. Our research group has chosen to use labile covalent linkages to ensure that the template-monomer adduct can be prepared stoichiometrically (i.e. in a 1:1 ratio) so that a more homogeneous distribution of binding sites forms upon polymerization. Three different vinyl monomers capable of imine formation with primary amines have been synthesized and analyzed for their ability to selectively bind the arthritic drug glucosamine over its structural isomer galactosamine. The results of this research have implications for future drug design and delivery systems as well as solid phase extraction applications.
Template and target information: glucosamine