MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Haginaka J, Takehira H, Hosoya K, Tanaka N
Article Title: Molecularly imprinted uniform-sized polymer-based stationary phase for naproxen - Comparison of molecular recognition ability of the molecularly imprinted polymers prepared by thermal and redox polymerization techniques.
Publication date: 1998
Journal: Journal of Chromatography A
Volume: 816
Issue: (2)
Page numbers: 113-121.
DOI: 10.1016/S0021-9673(98)00474-9

Abstract: A molecularly imprinted uniform-sized polymer-based stationary phase for (S)-naproxen has been prepared by a multi-step swelling and thermal or redox polymerization method using 4-vinylpyridine and ethylenedimethacrylate as a host functional monomer and cross-linker, respectively. The obtained molecularly imprinted polymers were evaluated using aqueous-rich mobile phases. The molecularly imprinted polymer materials could separate naproxen enantiomers. Further, the materials showed high selectivity for naproxen and moderate selectivity for other 2-arylpropionic acid derivatives. On the other hand, the molecularly imprinted polymer materials showed little selectivity for other acidic compounds, and basic and neutral compounds. With regard to comparison of the molecularly imprinted polymers prepared by thermal and redox polymerization techniques, the latter materials gave higher retentivity and enantioselectivity than the former materials, while the former materials gave higher column efficiency than the latter materials. Thus, naproxen enantiomers were resolved much better on the molecularly imprinted polymer material prepared by a thermal polymerization method. (C) 1998 Elsevier Science B.V. All rights reserved


  Neon periodic table mug  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner