MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Book Chapter
Authors: Alvarez-Lorenzo C, Concheiro A
Publication date: 2006
Chapter title: Molecularly imprinted materials as advanced excipients for drug delivery systems.
Chapter number: 10
Page numbers: 225-268.
DOI: 10.1016/S1387-2656(06)12007-4 Alternative URL: http://www.sciencedirect.com/science/article/B7CTS-4M345D7-B/2/4866d9d7fd326114fba6b1951047e57b

Book title: Biotechnology Annual Review
Editors: El-Gewely MR
Publisher: Elsevier
Volume number: 12

Abstract: The application of the molecular imprinting technology in the design of new drug delivery systems (DDS) and devices useful in closely related fields, such as diagnostic sensors or biological traps, is receiving increasing attention. Molecular imprinting technology can provide polymeric materials with the ability to recognize specific bioactive molecules and with a sorption/release behaviour that can be made sensitive to the properties of the surrounding medium. In this review, an introduction to the imprinting technology presenting the different approaches in preparing selective polymers of different formats is given, and the key factors involved in obtaining of imprinted binding sites in materials useful for pharmaceutical applications are analysed. Examples of DDS based on molecularly imprinted polymers (MIPs) can be found for the three main approaches developed to control the moment at which delivery should begin and/or the drug release rate; i.e., rate-programmed, activation-modulated or feedback-regulated drug delivery. This review seeks to highlight the most remarkable advantages of the imprinting technique in the development of new efficient DDS as well as to point out some possibilities of adapting the synthesis procedures to create systems compatible with both the relative instable drug molecules, especially of peptide nature, and the sensitive physiological tissues with which MIP-based DDS would enter into contact when administered. The prospects for future development are also analysed. 2006 Elsevier B.V. All rights reserved


  SMI logo tote bag  Mug featuring the name Carmen spelled out in the single letter amino acid code  Lab Chick script shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner