MIPdatabase
Authors: Sambe H, Hoshina K, Moaddel R, Wainer IW, Haginaka J
Article Title: Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization.
Publication date: 2006
Journal: Journal of Chromatography A
Volume: 1134
Issue: (1-2)
Page numbers: 88-94.
DOI: 10.1016/j.chroma.2006.08.073
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4KWTFFH-2/2/8945fafd2a53af166bf216fde07bdbb4
Abstract: Uniformly-sized, molecularly imprinted polymers (MIPs) for (S)-nicotine have been prepared by a precipitation polymerization method using methacrylic acid (MAA) or 2-(trifluoromethyl)acrylic acid (TFMAA) as a functional monomer and divinylbenzene (DVB) as a cross-linker in a mixture of toluene and acetonitrile. The (S)-nicotine-imprinted MAA-co-DVB polymers were monodispersed microspheres of about 4 μm in diameter, while the TFMAA-co-DVB ones were gel-like. Molecular recognition abilities of the former MIPs were evaluated for nicotine and its structurally related compounds in liquid chromatography using a mixture of sodium phosphate buffer and acetonitrile as the eluent. Enantioseparation of nicotine was attained using the (S)-nicotine-imprinted MAA-co-DVB polymers. Furthermore, they could selectively trap nicotine in cigarette smoke extracts
Template and target information: (S)-nicotine, nicotine
Author keywords: molecularly imprinted polymer, nicotine, precipitation polymerization, chiral separation, molecular recognition, Cigarette smoke extract
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