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Reference type: Journal
Authors: Deng QL, Lun ZH, Gao RY, Zhang LH, Zhang WB, Zhang YK
Article Title: S-Ibuprofen-imprinted polymers incorporating γ-methacryloxypropyl-trimethoxysilane for CEC separation of ibuprofen enantiomers.
Publication date: 2006
Journal: Electrophoresis
Volume: 27
Issue: (21)
Page numbers: 4351-4358.
DOI: 10.1002/elps.200600180
Alternative URL: http://www.proteomics.dicp.ac.cn/publications/2006/5.pdf

Abstract: In this report, a novel preparation method of molecularly imprinted polymers (MIPs) for CEC was developed. Molecularly imprinted monolithic columns for (S)-ibuprofen were prepared and evaluated, in which charged entities responsible for establishing EOF have been derived from γ-methacryloxypropyltrimethoxysilane (γ-MAPS), which was hydrolyzed following copolymerization with 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate(EDMA). The EOF and molecular recognition of the stationary phase were investigated in aqueous and nonaqueous media, respectively. The experimental results indicated that the material showed a reasonably stable EOF and the prepared separation materials were capable of separating racemic ibuprofen, a task that could not be accomplished by MIPs prepared in parallel, using methacrylic acid (MAA) as a functional monomer. The efficiency at pH3.2 for the first-eluted enantiomer and the last-eluted enantiomer (the imprinted analyte) were 128700 and 2100plates/m, respectively
Template and target information: (S)-ibuprofen
Author keywords: capillary electrochromatography, chiral recognition, ibuprofen, molecularly imprinted polymer


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