Authors: Sumaoka J
, Shirasaka K
, Katayama M
, Song S
, Nagaoka S
, Asanuma H
, Komiyama M
Recognition of bioactive oligopeptide by imprinted cyclodextrin polymer in water.
Publication date: 2006
Journal: Polymer Preprints, Japan
Abstract: We prepared molecularly imprinted polymers of ?-cyclodextrin using three bioactive oligopeptides as templates; (a) angiotensin I (10-mer), (b) ?-endorphin (17-mer), and (c) leucine-enkephalin (Leu-Enk: 6-mer). With both angiotensin I and Leu-Enk as the templates, highly precise imprinting effects were observed. The present finding strongly indicates that we can prepare artificial antibodies by imprinting of CyD to a conformationally restrained part of a protein
Template and target information: oligopeptides, endorphin, leucine-enkephalin, angiotensin I
Author keywords: cyclodextrin, imprinted polymer, molecular recognition, oligopeptide
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