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Book title: Chirality in Drug Research
Editors: Francotte E, Lindner W
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Series title: Methods and Principles in Medicinal Chemistry
Series editors: Mannhold R, Kubinyi H, Folkers G

Abstract: This chapter contains sections titled: Introduction The Role of Enantioselective Analysis in Drug Development Separation Techniques in Enantiomer Analysis Principle of Enantiomer Separation Indirect Enantiomer Separation Direct Enantiomer Separation Chiral Mobile Phase Additives (CMPA) Chiral Stationary Phases Molecular Requirements for Chiral Recognition Thermodynamic Principles of Enantiomer Separation Role of Mobile Phase in Enantiomer Separation Chiral Selectors and Chiral Stationary Phases Employed in Liquid Chromatographic Enantiomer Separation CSPs Derived from Polymers CSPs Derived from Natural Polymers Polysaccharide-type CSPs Protein-type CSPs CSPs Derived from Synthetic Polymers Helical Poly(methacrylates) Chiral Poly(methacrylamides) Tartardiamide-network Polymers Poly(diaminocyclohexane-N,N-diacrylamide) Molecularly Imprinted Polymers Macrocyclic CSPs Cyclodextrin-type CSPs Glycopeptide-type CSPs Crown Ether-type CSP CSPs Based on Low-Molecular-Weight Molecules Donor-Acceptor-type CSPs Ion-exchange-type CSPs Ligand-exchange-type CSPs CSPs Based on Target-specific Bioaffinity Systems Antibody-type CSPs Aptamer-type CSPs Conclusions References
Template and target information: Review - drug analysis
Author keywords: chirality, drug research, separations, stereoselective chromatographic methods, drug analysis, role of enantioselective analysis in drug development, separation techniques, principle of enantiomer separation, molecular requirements, thermodynamic principles of enantiomer separation, role of mobile phase, liquid chromatographic enantiomer separation