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Reference type: Journal
Authors: Haginaka J, Kagawa C
Article Title: Uniformly sized molecularly imprinted polymer for d-chlorpheniramine - Evaluation of retention and molecular recognition properties in an aqueous mobile phase.
Publication date: 2002
Journal: Journal of Chromatography A
Volume: 948
Issue: (1-2)
Page numbers: 77-84.
DOI: 10.1016/S0021-9673(01)01262-6
Alternative URL: http://144.206.159.178/FT/553/51949/911780.pdf

Abstract: A uniformly sized molecularly imprinted polymer (MIP) for d-chlorpheniramine has been prepared by a multi-step swelling and polymerization method using methacrylic acid and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively. The retentive and enantioselective properties of chlorpheniramine and its structurally related compounds on the MIP were evaluated using an aqueous mobile phase. Electrostatic and hydrophobic interactions could mainly work for the retention and enantioseparation of chlorpheniramine in aqueous mobile phase. Further, the MIP showed the highest recognition for chlorpheniramine and slight recognition for its structurally related compounds, and enantioseparation of pheniramine was attained. (C) 2002 Elsevier Science B.V. All rights reserved
Template and target information: d-chlorpheniramine


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