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Reference type: Journal
Authors: O'Connor NA, Paisner DA, Huryn D, Shea KJ
Article Title: Screening of 5-HT1A Receptor Antagonists using Molecularly Imprinted Polymers.
Publication date: 2007
Journal: Journal of the American Chemical Society
Volume: 129
Issue: (6)
Page numbers: 1680-1689.
DOI: 10.1021/ja067276c
Alternative URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192871/

Abstract: Abstract: Molecular imprinting produces network polymers with recognition sites for imprint molecules. The high binding affinity and selectivity in conjunction with the polymers' physical robustness positions molecular imprinted polymers (MIPs) as candidates for use as preliminary screens in drug discovery. As such, MIPs can serve as crude mimics of native receptors. In an effort to evaluate the relationship between MIPs and native receptors, imprinted polymers for WAY-100635, an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A were prepared. The resulting MIP P(WAY) was evaluated as an affinity matrix in the screening of serotonin receptor antagonists with known affinities for the native receptor. Rough correlations in affinity between the synthetic P(WAY) and native receptor 5-HT1A were found. These findings provide some support for the analogy between MIPs and native receptors and their possible use as surrogates
Template and target information: WAY-100635, serotonin, 5-HT


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