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Abstract: Molecularly imprinted polymers (MIPs) were generated for trans-aconitic acid 1 and cocaine 2 in a variety of porogens (CH3CN, CHCl3, [bmim][BF4], and [bmim][PF6]). MIP synthesis in either [bmim][BF4] or [bmim][PF6] resulted in significant acceleration of polymerization rates and, in the case of low temperature polymerizations, reactions were complete in less than 2 h, while no product was observed in the corresponding volatile organic carbon (VOC) porogen. In all instances, MIPs generated in [bmim][BF4] or [bmim][PF6] returned imprinting selectivities (I values) on par with or better than the corresponding MIP generated in VOCs. Imprinting values ranged between I = 1 and 2.9, with rebinding limited to 1 h. MIP synthesis conducted at low temperature (5 °C) afforded the highest I values. Scanning electron microscopy examination of MIP morphology highlighted an unexpected template effect with MIP structure varying between discrete nanoparticles and robust monoliths. This template-monomer interaction was also observed in the rates of polymerizations with differences noted in reaction times for 1 and 2 MIPs, thus providing indirect conformation of our previously proposed use of molecular modelling-nuclear magnetic resonance titrations (the MM-NMR method) in the design phase of MIP generation. In addition, considerable batch-to-batch rebinding selectivities were observed
Template and target information: trans-aconitic acid, cocaine