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Reference type: Journal
Authors: Kubo T, Matsumoto H, Shiraishi F, Nomachi M, Nemoto K, Hosoya K, Kaya K
Article Title: Selective separation of hydroxy polychlorinated biphenyls (HO-PCBs) by the structural recognition on the molecularly imprinted polymers: Direct separation of the thyroid hormone active analogues from mixtures.
Publication date: 2007
Journal: Analytica Chimica Acta
Volume: 589
Issue: (2)
Page numbers: 180-185.
DOI: 10.1016/j.aca.2007.02.070
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4N6FFTK-1/2/860655d92219437312772062cc028a44

Abstract: We developed novel separation media for hydroxy polychlorinated biphenyls (HO-PCBs) using the molecular imprinting techniques. The results of evaluation for the molecularly imprinted polymers (MIPs) by the liquid chromatography (LC) suggested that MIPs had selective separation ability for certain HO-PCB analogues. The results of the LC evaluations and molecular modeling indicated that the molecular volumes and pKa values of template molecules were related with the retention factor of HO-PCBs. Additionally, according to the detail evaluation toward the selective separation behaviors of MIPs, these HO-PCB analogues have low pKa values dependent on their chemical structures. In other words, the prepared MIPs had selective recognition ability against the analogues, which have an OH group on a phenyl carbon and two chlorine atoms on the both neighboring carbons of the carbon attached with the OH group. Moreover, these analogues may have a potential for thyroid hormone activities so that we attempted to separate these analogues directly from mixtures of HO-PCBs using a prepared MIP
Template and target information: hydroxy polychlorinated biphenyls, HO-PCBs, p-tert-butyl phenol, TBP, p-tert-butyl benzoic acid, TBBA, 2,6-bis-(trifluoromethyl)-benzoic acid, BTFB, Biphenyl-4-ol, Bol, Biphenyl-4-carboxylic acid, BCA
Author keywords: Hydroxy polychlorinated biphenyl (HO-PCB), molecular imprinting, selective separation, pKa, Thyroid hormone activity


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