MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Dzygiel P, O'Donnell E, Fraier D, Chassaing C, Cormack PAG
Article Title: Evaluation of water-compatible molecularly imprinted polymers as solid-phase extraction sorbents for the selective extraction of sildenafil and its desmethyl metabolite from plasma samples.
Publication date: 2007
Journal: Journal of Chromatography B
Volume: 853
Issue: (1-2)
Page numbers: 346-353.
DOI: 10.1016/j.jchromb.2007.03.037
Alternative URL: http://www.sciencedirect.com/science/article/B6X0P-4NFR59V-3/2/242b8e9d67ba283417c065a932e481c6

Abstract: The evaluation of molecularly imprinted polymers (MIPs) as selective sorbents for the solid-phase extraction of sildenafil and its principal metabolite, desmethylsildenafil, was investigated. Two MIPs were synthesised using structural analogues of sildenafil as templates, and a comparison of the performance of the two MIP sorbents in organic and aqueous media was performed. Additionally, the feasibility of applying molecularly imprinted solid-phase extraction (MISPE) to the clean-up of plasma samples containing sildenafil and desmethylsildenafil was investigated. A preliminary, quantitative MISPE for the determination of both compounds in plasma was also performed. The results showed that the MIPs used for the selective extraction of sildenafil gave better compound recovery when aqueous samples were used in comparison to organic-based samples. A preliminary, quantitative MISPE of sildenafil and desmethylsildenafil indicated that the imprinted materials could be used successfully as SPE sorbents for sample pre-treatment for the determination of sildenafil, and related compounds, in plasma
Template and target information: sildenafil, desmethylsildenafil, Viagra
Author keywords: Molecularly imprinted polymers, Sildenafil, Solid-phase extraction


  SMI logo shirt  Mug featuring the name Peter spelled out in the single letter amino acid code  Lab Chick script shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon