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Reference type: Journal
Authors: Haginaka J, Tabo H, Ichitani M, Takihara T, Sugimoto A, Sambe H
Article Title: Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate, -epicatechin gallate and -gallocatechin gallate by multi-step swelling and polymerization method.
Publication date: 2007
Journal: Journal of Chromatography A
Volume: 1156
Issue: (1-2)
Page numbers: 45-50.
DOI: 10.1016/j.chroma.2006.10.026
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4M6SBJ0-3/2/b9a2a88b167cd34f267dc596c1dd4b4f

Abstract: Uniformly-sized, molecularly imprinted polymers (MIPs) for (-)-epigallocatechin gallate (EGCg), -epicatechin gallate (ECg) and -gallocatechin gallate (GCg) were prepared by a multi-step swelling and polymerization method using 2-vinylpyridine as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and cyclohexanol as a porogen. Molecular recognition abilities of the obtained MIPs were evaluated in liquid chromatography using a mixture of ethanol and water, or ethanol as the eluent. Each MIP gave the highest molecular recognition ability for the respective template molecule. In addition, (-)-EGCg and -ECg had the same configuration (2R,3R) at positions 2 and 3, and therefore resulting in high cross reactivity each other. However, (-)-GCg, which has different configuration at position 2 with (-)-EGCg and -ECg, showed low cross reactivity with them. On the other hand, those MIPs showed no molecular recognition against (-)-epigallocatechin and -epicatechin, which have no gallate group at position 3. These results indicate that the MIPs prepared can recognize configuration at position 2 and a gallate group at position 3. Furthermore, the MIP for (-)-GCg could be successfully used for isolating (-)-EGCg and -ECg from green tea extract
Template and target information: (-)-epigallocatechin gallate, EGCg, (-)-epicatechin gallate, ECg, (-)-gallocatechin gallate, GCg
Author keywords: molecular recognition, molecularly imprinted polymer, LC stationary phase, Epigallocatechin gallate, Epicatechin gallate, Gallocatechin gallate

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