Abstract: Molecularly imprinted polymeric microspheres (MIPMs) for S-naproxen were prepared in aqueous system by a one-step swelling and polymerization. The figurations and pore structures of the MIPMs were analyzed by scanning electron microscope and nitrogen adsorption, and the adsorption and recognition properties of the MIPMs were studied. Results of the studies indicated that molecularly imprinted polymer beads prepared by one-step swelling and polymerization had narrow size distribution (ň<2.0 % ), and the dosage of chloroform and crosslinker influenced the configuration, pore diameter, pore diameter distribution and surface area of the MIPMs. Scatchard analysis shown the MIPMs recognizing S-naproxen with two classes of binding sites. The calculated dissociation constant Kdl and apparent maximum number Qmaxl of binding sites with high affinity are 2. 13mmol/L and 36.46ýmol/g respectively,while Kd2 and Qmax2 of binding sites with low affinity are 31. 55mmol/L and 389.99ýmol/g.
Template and target information: S-naproxen
Author keywords: molecularly imprinted polymer, one-step swelling and polymerization, bead, S-naproxen, pore structure