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Abstract: Using a functional monomer(methyl methacrylate, acrylamide, ethyl acrylate or acrylic acid) and a crosslinker(TMPTA), molecularly imprinted polymers(MIPs) with recognition properties to dibenzoyl-L-tartaric acid(L-DBTA) were prepared by photopo-polymerization method in the presence of a template(L-DBTA) in acetonitrile solution. High-performance liquid chromatographic (HPLC) analysis of molecularly imprinted polymers (MIPs) of dibenzoyl-L-tartaric acid (L-DBTA) with recognition properties were conducted to evaluate the influences of various factors on DBTA binding. The experimental results indicated that the MIPs had higher L-DBTA binding ability than D-DBTA's and also higher than corresponding non-imprinted polymers. Based on Scatchard analysis, one kind of binding sites was formed in the L-DBTA MIPs. At 293.15?K, its equilibrium dissociation constant(K_d) was 0.064 mmol/L while the maximum apparent binding capacity(Q_m) was 6.4 mg/g. On the basis of isothermal binding thermodynamic investigation, the recognition mechanism between L-DBTA and MIP recognition group was described by Langmuir isothermal binding. Therefore, some thermodynamic parameters were obtained: Δ H=7.40 kJ/mol, Δ S=42.74 J/mol.K, Δ G_(298)=-5.34 kJ/mol. The kinetics analysis illustrated that the interaction between L-DBTA and MIP was very fast and the apparent activation energy was 7.40 kJ/mol.
Template and target information: dibenzoyl-L-tartaric acid, L-DBTA
Author keywords: MIP, molecular imprinting polymer, Dibenzoyl-L-tartaric acid, photopolymerization, chiral recognition, activation energy