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Abstract: Objective: To evaluate and screen out a new selective solid phase sorbent for nerve agent degradation products and study the influencing factors and mechanism of molecularly imprinted polymers(MIPs).Methods:A series of MIPs were synthesized with nerve agent degradation products(such as EMPA, i-BuMPA and PMPA, they are the degradation of VX, RVX and GD respectively) as template with different functional monomers, crosslinker and solvent and were used as solid phase extraction(SPE) sorbents. The adsorption ratio of MIPs to the nerve agent degradation products in acetonitrile solution was determined by derivative GC. Influences of functional monomers, crosslinker, progenic solvent, temperature and the granularity of MIP etc. on the recognition behavior were investigated. Results: The recognition ability of the MIPs were strongly influenced by the type and amount of monomer and crosslinker. The experiment indicated that MIP prepared using acrylamide as monomer and ethylene-glycol dimethacrylate as crosslinker was most suitable MIP for corresponding templates. On the other hand, the structure of template was another important factor influencing MIP's binding behavior. MIPs synthesized could strongly adsorb the six nerve agent degradation products. The ratio of adsorption of MIPs was relevant to the structure of the degradation products. Conclusion: MIPs synthesized could be used as common sorbents for extraction, separation and enrichment of nerve agent degradation products in practical samples.
Template and target information: nerve agent degradation products, EMPA, i-BuMPA, PMPA
Author keywords: chemical warfare agents, poisons, adsorption, chromatography, GAS, molecularly imprinted polymer, solid phase extraction, nerve agent degradation products