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Abstract: Molecularly-imprinted polymeric microspheres(MIPM) were prepared via a one-step swelling and polymerization method,with 2,4-dichloro-6,7-dimethoxyquinazoline(DCQAL) as the template molecule.The effects of the functional monomer,the molar ratio of the template molecule to the functional monomer,the crosslinker do-sage and the additive of adsorption solution on the recognition capabilities of MIPM were then investigated.The results indicate that(1) the MIPM prepared using acidic functional monomers can form stronger hydrogen bond with basic DCQAL,thus resulting in good recognition capabilities for DCQAL,the separation factor is up to 1.83 or 2.02 when 4-chloro-6,7-dimethoxyquinazoline or 2,3-dimethylquinoxaline is chosen as the competitive molecule;(2) an increase in the crosslinker dosage may enhance the stability of the imprinted cavity of MIPM and thus improves the recognition capabilities of MIPM;(3) when increasing the molar ratio of the template molecule to the functional monomer,more functional monomers can be regularly arranged in MIPM to achieve better recognition capabilities;and(4) the addition of a small quantity of triethylamine(less than 0.1%) to the adsorption solution can decrease the non-specific adsorption of MIPM,thus improving the recognition capabilities.
Template and target information: 2,4-dichloro-6,7-dimethoxyquinazoline, DCQAL
Author keywords: molecular imprinting, one-step swelling, microsphere, synthesis, quinazoline, Recognition