MIPdatabase
Authors: Oxelbark J, Legido-Quigley C, Aureliano CSA, Titirici MM, Schillinger E, Sellergren B, Courtois J, Irgum K, Dambies L, Cormack PAG, Sherrington DC, De Lorenzi E
Article Title: Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats.
Publication date: 2007
Journal: Journal of Chromatography A
Volume: 1160
Issue: (1-2)
Page numbers: 215-226.
DOI: 10.1016/j.chroma.2007.05.057
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4NTBFJX-3/2/3f71ba0b064fbbe7082f091d9594b8c6
Abstract: A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study
Template and target information:
Author keywords: Molecularly imprinted polymers, bupivacaine, frontal chromatography, Capillary monolith, microspheres, iniferter
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