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Abstract: OBJECTIVE: To investigate the molecular recognition mechanism of molecularly imprinted polymer (MIP) and its influence factors. METHODS: MIPs were prepared with anticholinergic drug neotropine as template, methacrylic acid (MAA) as functional monomer and trimethylolpropane trimethacrylate (TRIM) as crosslinker. The specific solid phase extraction of MIPs was investigated for anticholinergic drugs: neotropine, penequinine, bencynonatine and anisodine, chlorphenamine with different hydrogen-band groups. RESULTS: The results showed that the recognition ability of MIPs was associated closely with the conditions of synthesis and experiment. The specific molecular recognition was observed for anticholinergic drugs and weak adsorption for anisodine and chlorphenamine. CONCLUSION: The experiments reveal that the non-specific adsorption of MIPs could mainly result from the hydrogen-band of polar groups between MIPs and analytes. The steric shape complementary between analytes and the recognition sites of MIPs plays a key role in the molecular recognition progress
Template and target information: neotropine
Author keywords: anticholinergic drugs, molecularly imprinted polymer, solid phase extraction