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Volume number: 2
Conference information: 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

Abstract: In this study, a molecularly imprinted polymer (MIP) based uric acid sensor was fabricated using a novel amineimide type conducting polymer. Calibration curves of the sensor were depicted based on the amperometric steadystate current in different concentrations of UA ranging from 0 to 1.125 mM. The sensitivities of MIP and non-MIP electrodes were calculated to 24.72 and 6.63 μA mM -1 cm-2, respectively. The imprinting efficiency, defined as the ratio of the sensitivity of MIP to that of NMIP electrode, was 3.7 in this work. The limit of detection (LOD) for the MIP-ITO/Poly(PD-BCD) UA electrode was calculated to be 2.4 x 10-3 mM on the basis of signal to noise ratio (S/N) equaling to 3. It was found that the MIP sensor showed relatively good sensitivity, large linear range, and high imprinting efficiency with a low LOD for sensing UA. The MIP-ITO/Poly(PD-BCD) UA electrode was also tested for ascorbic acid (AA), and the current response of 0.04 mM AA is less than 7 % of the current response of 0.4 mM UA
Template and target information: uric acid, UA
Author keywords: Amperometric, Molecularly imprinted polymers, uric acid, Uric acid biosensors