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Reference type: Journal
Authors: Hosoya K, Yoshizako K, Shirasu Y, Kimata K, Araki T, Tanaka N, Haginaka J
Article Title: Molecularly imprinted uniform-size polymer-based stationary phase for high-performance liquid chromatography - Structural contribution of cross-linked polymer network on specific molecular recognition.
Publication date: 1996
Journal: Journal of Chromatography A
Volume: 728
Issue: (1-2)
Page numbers: 139-147.
DOI: 10.1016/0021-9673(95)01165-X

Abstract: Non-covalently molecularly imprinted, uniform-size, polymer-based, stationary phases were prepared by a two-step swelling technique using isomers of diaminonaphthalene or a chiral amide derived from (S)-alpha-methylbenzylamine as the template molecule. Methacrylic acid worked as an effective host molecule for diaminonaphthalene templates, however, an imprinted, cross-linked, polymer-based, stationary phase without such a relatively strong host functionality unexpectedly showed moderate molecular recognition, which suggested that the cross-linked polymer network could memorize the shape of a template. In chiral separation of amide derivatives, a cross-linked polymer network also memorized the shape of a chiral template, resulting in chiral resolution. In addition, a chiral cross-linking agent having similar functionality to the chiral amide template could enhance molecular recognition drastically. Further studies suggested that this enhancement in chiral recognition was due to a favorable structural interaction within the specific recognition sites


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