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Reference type: Journal
Authors: Boyd B, Bjork H, Billing J, Shimelis O, Axelsson S, Leonora M, Yilmaz E
Article Title: Development of an improved method for trace analysis of chloramphenicol using molecularly imprinted polymers.
Publication date: 2007
Journal: Journal of Chromatography A
Volume: 1174
Issue: (1-2)
Page numbers: 63-71.
DOI: 10.1016/j.chroma.2007.08.072
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4PKFH4R-3/2/7b5cd88b59af72f561a86e04bc27500a

Abstract: A confirmatory method is described for the determination of the illegal antibiotic chloramphenicol using a specifically developed molecularly imprinted polymer (MIP) as the sample clean-up technique. The newly developed MIP was produced using an analogue to chloramphenicol as the template molecule. Using an analogue of the analyte as the template avoids a major traditional drawback associated with MIPs of residual template leeching or bleeding. The MIP described was used as a solid-phase extraction phase for the extraction of chloramphenicol from various sample matrices including honey, urine, milk and plasma. A full analytical method with quantification by LC-MS/MS is described. The method was fully validated according to the European Union (EU) criteria for the analysis of veterinary drug residues
Template and target information: chloramphenicol
Author keywords: chloramphenicol, molecularly imprinted polymer, SPE, Honey, urine, plasma, milk, Veterinary drug residues


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