MIPdatabase
Authors: Yang Y, Long YY, Cao Q, Li KA, Liu F
Article Title: Molecularly imprinted polymer using β-cyclodextrin as functional monomer for the efficient recognition of bilirubin.
Publication date: 2008
Journal: Analytica Chimica Acta
Volume: 606
Issue: (1)
Page numbers: 92-97.
DOI: 10.1016/j.aca.2007.10.044
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4R2962J-5/2/b3796f55ffee60a7800e9da6926cd3be
Abstract: Bilirubin (BR) imprinted polymer was successfully prepared using supramolecular host compound β-cyclodextrin (β-CD) as functional monomer. The adsorption equilibrium was attained in about 4 h, which indicated that the adsorption kinetics was comparatively fast. The results of adsorption and selectivity experiments indicated that BR-imprinted β-CD polymer was able to bind BR specifically and reversibly. The specific recognition of BR-imprinted β-CD polymer for BR may be due to the cooperative effects of inclusion interaction and hydrogen bonding. This BR-imprinted β-CD polymer was further applied to eliminate BR in human serum sample. It was verified that the binding specificity of the BR-imprinted polymer for BR was essentially sufficient in the presence of other compounds coexisting in serum sample. Therefore, as a reusable material possessing high affinity and selectivity, BR-imprinted β-CD polymer has a potential application perspective as a clinical hemoperfusion material
Author keywords: molecularly imprinted polymer, β-cyclodextrin, Bilirubin, selectivity
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