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Abstract: A dopamine-imprinted polymer (MIP) was prepared in aqueous methanol solution at 60 °C by free-radical cross-linking polymerization of methacrylic acid in the presence of ethylene glycol dimethacrylate as the cross-linker and dopamine hydrochloride as the template molecule. Its ability to isolate dopamine was evaluated as the basis of a solid phase extraction procedure and compared with that of a non-imprinted polymer (NIP). The binding of dopamine was 84.1% and 29.1% for MIP and NIP, respectively. Various reported post-polymerization treatments to reduce template bleeding were examined. In our case the lowest bleeding was achieved after applying a combined procedure: continuous extraction in a Soxhlet apparatus (CE), followed by microwave-assisted extraction (ME) to a level of 0.061 μg/mL. A simplified model of the template-monomer complexes allowed rationalization of monomer choice based on the heats of complex formation at a PM3 level of theory. ® 2007 by MDPI
Template and target information: dopamine
Author keywords: Dopamine hydrochloride isolation, molecularly imprinted polymer, solid phase extraction, Template removal, Theoretical binding energy