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Reference type: Journal
Authors: Mazzotta E, Picca RA, Malitesta C, Piletsky SA, Piletska EV
Article Title: Development of a sensor prepared by entrapment of MIP particles in electrosynthesised polymer films for electrochemical detection of ephedrine.
Publication date: 2008
Journal: Biosensors and Bioelectronics
Volume: 23
Issue: (7)
Page numbers: 1152-1156.
DOI: 10.1016/j.bios.2007.09.020
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4PT7WYB-2/2/fef1daff051655d5e01c31514d829e9f

Abstract: A voltammetric sensor for (-)-ephedrine has been prepared by a novel approach based on immobilisation of an imprinted polymer for ephedrine (MIPE) in an electrosynthesised polypyrrole (PPY) film. Composite films were grown potentiostatically at 1.0 V vs. Pt (QRE) on a glassy carbon electrode using an unconventional "upside-down" (UD) geometry for the three-electrode cell. As a consequence, a high MIP loading was obtained, as revealed by SEM. The sensor response was evaluated, after overoxidation of PPY matrix, by cyclic voltammetry after pre-concentration in a buffered solution of analyte in 0.5-3 mM concentration range. An ephedrine peak at [approximate]0.9 V increasing with concentration and saturating at high concentrations was evident. PPY-modified electrode showed a response, which was distinctly lower than the MIP response for the same concentration of the template. The effect of potential interferences including compounds usually found in human fluids (ascorbic acid, uric acid, urea, glucose, sorbitol, glycine, dopamine) was examined
Author keywords: molecular imprinting, Electrochemical sensor, polypyrrole, Ephedrine


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