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Reference type: Journal
Authors: Haginaka J, Futagami A
Article Title: Addition of N-carbobenzyloxy-l-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
Publication date: 2008
Journal: Journal of Chromatography A
Volume: 1185
Issue: (2)
Page numbers: 258-262.
DOI: 10.1016/j.chroma.2008.01.059
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4RR1NSY-4/2/448a9d2128c799ed4c452ae0fed728c8

Abstract: Molecularly imprinted polymer (MIP) monoliths for (+)-nilvadipine have been prepared using 4-vinylpyridine as a functional monomer and toluene/1-dodecanol as a porogen without or with addition of N-carbobenzyloxy-l-tryptophan (Cbz-l-Trp) as a co-template molecule. The MIP monoliths prepared with (+)-nilvadipine as a sole template molecule had no macro through-pores, while those could be formed by addition of Cbz-l-Trp as the co-template molecule. Furthermore, on the former nilvadipine enantiomers could not be separated, but on the latter they could. The presence of Cbz-l-Trp affected the polymerization process and resulted in forming macro through-pores of the MIP monoliths for (+)-nilvadipine and attaining separation of nilvadipine enantiomers. These results suggest that co-addition of Cbz-l-Trp could be effective for preparing MIP monoliths for (+)-nilvadipine, whose preparation is difficult
Author keywords: molecular imprinting, Molecularly imprinted polymer monolith, chiral separation, Nilvadipine, N-Carbobenzyloxy-l-tryptophan


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