MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Ulubayram K, Tunc Y, Baykara E
Article Title: Molecularly imprinted acrylic-based microspheres for colonic delivery of 5-aminosalicylic acid.
Publication date: 2007
Journal: Optoelectronics And Advanced Materials-Rapid Communications
Volume: 1
Issue: (6)
Page numbers: 312-316.
Alternative URL: http://oam-rc.inoe.ro/index.php?option=magazine&op=view&idu=299&catid=14

Abstract: Feasibility of molecularly imprinted polymeric microspheres (MIPs) has been investigated for colonic delivery of 5-aminosalicylic acid (5-ASA). 5-ASA imprinted microspheres were prepared by a single step precipitation polymerization of 2-(diethylamino) ethyl methacrylate (DEAEMA; functional monomer) and trimethylolpropane trimethacrylate (TRIM; crosslinker). The release profiles of 5-ASA imprinted and non-imprinted microspheres were evaluated. We present a precipitation polymerization method for preparing uniform molecularly imprinted microspheres in micron range, quickly and cleanly. Monodisperse polymer particles with good spherical shapes and smooth surfaces were obtained. Furthermore, the imprinted microspheres have a slower 5-ASA release in the initial stages than the non-imprinted microspheres, because of the interaction of the drug molecules with the recognition sites in the imprinted microspheres. This result showed that molecular imprinting may have a potential for controlled delivery of drugs
Template and target information: 5-aminosalicylic acid, 5-ASA
Author keywords: molecular imprinting, colonic delivery, 5-aminosalicylic acid, precipitation polymerization, microspheres, 2-(diethylamino) ethyl methacrylate, trimethylolpropane trimethacrylate


  mipdatabase.com logo imprinters do it in bulk shirt  Science Teacher peptide mug  Perpetual student shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner