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Reference type: Journal
Authors: Breton F, Delépée R, Jégourel D, Deville-Bonne D, Agrofoglio LA
Article Title: Selective adenosine-5'-monophosphate uptake by water-compatible molecularly imprinted polymer.
Publication date: 2008
Journal: Analytica Chimica Acta
Volume: 616
Issue: (2)
Page numbers: 222-229.
DOI: 10.1016/j.aca.2008.04.025
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4S98V0T-5/1/db75cb091aef592ed6c300188216ab6d

Abstract: Molecularly imprinted polymers (MIPs) were prepared for adenosine-5'-monophosphate (AMP), a substrate of AMP-activated protein kinase. The template molecule was formed by the vinylphenylboronate diester of adenosine on which 5'-free hydroxide was protected by tert-butyldimethylsilyl group in order to mimic the steric hindrance of the phosphate moiety of AMP. Molecular imprinting was performed by complexing acrylamide and the template in a highly cross-linked polymer. MIPs were tested in batch experiments with aqueous samples of nucleotides and a number of parameters were investigated. The use of tetrabutylammonium hydroxide (TBAH) was necessary to obtain a rebinding of nucleotides on MIP. The adsorption of AMP was optimal in 5 mM ammonium acetate buffer solution pH 9.5 for 30 min, with 30 mM of TBAH. The imprinted polymer was selective for AMP towards others nucleotides or deoxi analogues
Template and target information: adenosine-5'-monophosphate, AMP
Author keywords: molecularly imprinted polymer, Adenosine monophosphate, Boronic acid, Water-compatible polymer


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