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Authors: Puoci F, Cirillo G, Curcio M, Iemma F, Parisi OI, Castiglione M, Picci N
Article Title: Molecularly Imprinted Polymers for α-Tocopherol Delivery.
Publication date: 2008
Journal: Drug Delivery
Volume: 15
Issue: (4)
Page numbers: 253-258.
DOI: 10.1080/10717540802006724
Abstract: Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on +¦ -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for +¦ -tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more +¦ -tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids
Template and target information: α-tocopherol, vitamin E
Author keywords: α-Tocopherol, Drug delivery system, Molecularly imprinted polymers
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