Alternatively for mipdatabase quick searches go here

Custom Search

Abstract: A molecularly imprinted polymer(MIP) with special molecule recognition properties of ciprofloxacin(CIP) was prepared by thermal polymerization in which ciprofloxacin as template molecule, α-methacrylic acid(MAA) as functional monomer and trimethylolpropane trimethylacrylate (TRIM) as crosslinker. The optimized ratio was determined to be n(CIP):n(MMA):n(TRIM) = 1:6:16 by investigated the effects of different concentrations of functional monomer and crosslinker on the MTP's recognition properties. Equilibrium binding experiment was used to investigate the adsorption dynamics, the binding ability to template molecule and the substrate selectivity. The scatchard analysis was used to study that the MIP's binding characteristic to template molecule. The results indicated that the MIP has higher adsorption ability and selectivity. The equilibrium distribution coefficient KD was 41.64 and the separation factor α was 1.62. Scatchard analysis showed that two different kinds of binding sites were produced in the polymer matrix and their dissociation constants were calculated to be Kd1 = 5.249 + 10-5 mol+L-1, Kd2 = 2.237 + 10-3 mol+L-1
Template and target information: ciprofloxacin, CIP
Author keywords: Adsorption characteristic, Ciprofloxacin, molecularly imprinted polymer