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Abstract: A new molecularly imprinted polymer was synthesised based on sacrificial mesoporous silica (Si-MIP) for the solid-phase extraction of fluoroquinolone residues in edible animal products. The Si-MIP was prepared by filling mesoporous silica with the template molecule and monomers followed by polymerisation, then the silica particles materials were removed from the obtained imprinted composites. The binding capacity was evaluated by static adsorption and Scatchard analysis, which showed that the dissociation constant (KD) and the maximum binding capacity (Qmax) were 178.9 mg L-1 and 73.31 mg g-1 for high affinity binding site, and 45.54 mg L-1 and 40.82 mg g-1 for lower affinity binding site, respectively. The largest selectivity coefficient for ofloxacin in the presence of enrofloxacin was found to be 3.79, the largest relative selectivity coefficient between ofloxacin and enrofloxacin over 3, along with a fast kinetics comparing with MIP without silica template. The SPE procedure was optimized, and the accuracy and selectivity of Si-MIP cartridge process developed were verified using a MIP cartridge and a classical C18 cartridge as the SPE matrix during control experiments. The quantification and detection limits in tissue samples of ofloxacin, enrofloxacin and flumequin and were established at 18 m g kg-1, 21 m g kg-1 and 42 m g kg -1, respectively. Copyright CGI
Template and target information: fluoroquinolone, ofloxacin, enrofloxacin, flumequin
Author keywords: Molecularly imprinted polymers, Quinolones, Silica gel as sacrificial material, Solid-phase extraction, Tissue sample