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Abstract: Despite the increasing number of applications of molecularly imprinted polymers (MIPs) in analytical chemistry, the construction of a biomimetic potentiometric sensor remains still challenging. In this work, a biomimetic potentiometric sensor, based on a non-covalent imprinted polymer was fabricated for the recognition and determination of cetirizine. The MIP was synthesized by precipitation polymerization, using cetirizine dihydrochloride as a template molecule, methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross linking agent. The sensor showed high selectivity and a sensitive response to the template in aqueous system. The MIP-modified electrode exhibited Nernstian response (28.0±0.9 mV/decade) in a wide concentration range of 1.0×10-6 to 1.0×10-2 M with a lower detection limit of 7.0×10-7 M. The electrode has response time of ca. 20 s, high performance, high sensitivity, and good long term stability (more than 5 months). The method was satisfactory and used to the cetirizine assay in tablets and biological fluids
Template and target information: cetirizine, cetirizine dihydrochloride
Author keywords: molecularly imprinted polymer, potentiometric sensor, biomimetic sensor, Cetirizine, biological fluids, tablets