MIPdatabase
Authors: Casey BJ, Kofinas P
Article Title: Selective binding of carcinoembryonic antigen using imprinted polymeric hydrogels.
Publication date: 2008
Journal: Journal of Biomedical Materials Research Part A
Volume: 87A
Issue: (2)
Page numbers: 359-363.
DOI: 10.1002/jbm.a.31757
Abstract: A poly(allylamine hydrochloride) carcinoembryonic antigen-imprinted hydrogel was synthesized using a water-soluble crosslinker, ethylene glycol diglycidyl ether, to investigate its viability for protein recognition. The imprinting factor of the imprinted hydrogel toward carcinoembryonic antigen was found to be sim5, while the imprinting factor of the imprinted hydrogel toward alpha-fetoprotein was determined to be sim2, suggesting selectivity and specificity toward the template protein. This work lays the foundation for the development of a novel line of imprinted hydrogel systems capable of protein recognition for diagnostic and therapeutic applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008
Template and target information: protein, carcinoembryonic antigen
Author keywords: carcinoembryonic antigen, hydrogel, molecular imprinting, protein recognition
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