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Reference type: Journal
Authors: Jégourel D, Delépée R, Breton F, Rolland A, Vidal R, Agrofoglio LA
Article Title: Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine.
Publication date: 2008
Journal: Bioorganic & Medicinal Chemistry
Volume: 16
Issue: (19)
Page numbers: 8932-8939.
DOI: 10.1016/j.bmc.2008.08.063
Alternative URL: http://www.sciencedirect.com/science/article/B6TF8-4TB183H-3/2/fc733efc0d4009d3f08d52db09960d19

Abstract: Normal and modified urinary nucleosides represent potential biomarkers for cancer diagnosis. To selectively extract modified nucleosides, we developed a molecularly imprinted polymer (MIP) of 5-methyluridine as selective material for molecularly imprinted solid-phase extraction (MISPE). The MIPs were obtained from vinyl-phenylboronate ester derivative of the template, acrylamide and pentaerythritol triacrylate co-polymer, and were tested in batch and cartridge experiments with aqueous samples. Our results indicated that the imprinted polymer was selective for pyrimidine nucleosides with a Kd and a Bmax of 46áμM and 18áμmol/g, respectively. Finally, a MISPE of the most common pyrimidine nucleoside cancer markers in urine sample was realized
Template and target information: 5-methyluridine, pyrimidine nucleosides
Author keywords: 5-Methyluridine, Cancer markers, molecularly imprinting polymer, Pyrimidinic nucleosides, MISPE, urine


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