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Reference type: Journal
Authors: Baydemir G, Bereli N, Andaç M, Say R, Galaev IY, Denizli A
Article Title: Bilirubin recognition via molecularly imprinted supermacroporous cryogels.
Publication date: 2009
Journal: Colloids and Surfaces B: Biointerfaces
Volume: 68
Issue: (1)
Page numbers: 33-38.
DOI: 10.1016/j.colsurfb.2008.09.008
Alternative URL: http://www.sciencedirect.com/science/article/B6TFS-4TG9HRW-2/2/3732ac089ec80d53875c5cbc836a2ba8

Abstract: Recent years molecular imprinting has received considerable attention as an excellent and simple approach to recognize small molecules and bioactive substances. The aim of this study is to prepare the bilirubin-imprinted supermacroporous cryogels which can be used for the adsorption of bilirubin from human plasma. N-methacryloyl-(l)-tyrosinemethylester (MAT) was chosen as the pre-organization monomer. In the first step, bilirubin was complexed with MAT and the bilirubin-imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(l)-tyrosine methylester) [BR-MIP] cryogel was produced by free radical polymerization initiated by N,N,N',N'-tetramethylene diamine (TEMED) and ammonium persulfate (APS) pair in an ice bath. After that, the template molecules (i.e., bilirubin) were removed from the polymeric structure using sodium carbonate and sodium hydroxide. The maximum bilirubin adsorption amount was 3.6ámg/g polymer. The relative selectivity coefficients of the BR-MIP cryogel for bilirubin/cholesterol and bilirubin/testosterone mixtures were 7.3 and 3.2 times greater than non-imprinted poly(HEMA-MAT) [NIP] cryogel, respectively. The BR-MIP cryogel could be used many times without decreasing bilirubin adsorption amount significantly. Therefore, as a reusable carrier possessing high selectivity, BR-MIP cryogel has a potential candidate as a clinical hemoperfusion material
Template and target information: bilirubin
Author keywords: Cryogels, molecular imprinting, molecular recognition, Bilirubin, affinity binding


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