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Abstract: Molecularly imprinted polymers (MIPs) are an interesting novel class of sorbent for analytical separation science, with one particular area of potential being in the development of highly selective solid-phase extraction systems. In order to optimise polymer-ligand selectivity and to examine the underlying physical mechanisms, polymers with selectivity for the local anaesthetic bupivacaine have been synthesised and their ligand- recognition characteristics examined. The influence of rebinding media parameters (pH, ionic strength, polarity) have been studied and optimised with respect to selective MIP-ligand binding, and the working range of the polymers with respect to these parameters has been mapped. These results highlight the robustness of MIPs and the breadth of potential assay conditions that may be employed. Finally, competitive binding studies using the closely related structures mepivacaine, ethycaine, ropivacaine and pentycaine in solvent mixtures of different polarity revealed that the entropy-driven hydrophobic effect is significant in polar solvents, whereas enthalpy- driven electrostatic interactions dominate in non-polar media. (C) 2001 Elsevier Science B.V. All. rights reserved
Template and target information: bupivacaine