MIPdatabase
Authors: Rezaei B, Mallakpour S, Majidi N
Article Title: Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum.
Publication date: 2009
Journal: Talanta
Volume: 78
Issue: (2)
Page numbers: 418-423.
DOI: 10.1016/j.talanta.2008.11.042
Alternative URL: http://www.sciencedirect.com/science/article/B6THP-4V2NNXF-3/2/7a8f0fb4714a7d0fb9798b08b3f36c4a
Abstract: A selective molecularly imprinted polymer (MIP) has been synthesized for isoxicam pre-concentration, followed by its spectrophotometric determination based on hydrogen bonding interactions between examined drug and alizarin yellow GG. This method is able to evaluate isoxicam in range of 1.0 x 10-3 to 20.0 μg mL-1, with a limit of determination of 1.0 ng mL-1. The retention capacity and pre-concentration factor of prepared sorbent are 18.5 mg g-1 and 200, respectively; and the prepared MIPs can be reused at least for five times. The MIP capability for isoxicam selection and extraction from the solution is higher than non-imprinted polymer (NIP). Under optimum conditions, this procedure can be successfully applied to assay trace amounts of isoxicam in pharmaceutical and biological samples
Template and target information: isoxicam
Author keywords: molecularly imprinted polymer, Isoxicam, Spectrophotometry, Pharmaceutical and biological samples
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