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Reference type: Journal
Authors: Xu ZX, Chen SA, Huang W, Fang GZ, Pingzhu H, Wang S
Article Title: Study on an on-line molecularly imprinted solid-phase extraction coupled to high-performance liquid chromatography for separation and determination of trace estrone in environment.
Publication date: 2009
Journal: Analytical and Bioanalytical Chemistry
Volume: 393
Issue: (4)
Page numbers: 1273-1279.
DOI: 10.1007/s00216-008-2544-4

Abstract: Abstract: Estrone is one of the important potential endocrine-disrupting compounds, and the sensitive and reliable analytical methods for the determination of estrone are required for the assurance of human health. In this paper, using estrone as template molecule, 3-aminopropyltriethoxysilane as function monomer, and tetraethoxysilicane as cross-linker, a highly selective molecularly imprinted microsphere was synthesized by surface molecular imprinting technique combined with a sol–gel process. The imprinted material was characterized by the Fourier transform infrared and static adsorption experiments, and the results showed that it exhibited good recognition and selective ability for estrone. A novel method for separation and determination of trace estrone in environmental sample was developed using on-line molecularly imprinted solid-phase extraction coupled to high-performance liquid chromatography. With a sample loading flow rate of 2.6 mL min?1 for a 9.6-min extraction, the enrichment factor obtained by the slopes of the linear portion in comparison with the direct injection of 10 ?L standard sample solution was 1,045. The detection limit (S/N?=?3) was 5.7 ng L?1, and the relative standard deviations for nine replicate extractions of 5.0 ?g L?1 estrone was less than 10.0%. This method was evaluated for quantitative determination of estrone in well and lake water samples spiked at two levels (0.5 and 1.0 ?g L?1) with recoveries ranging from 86% to 95%
Template and target information: estrone
Author keywords: Estrone, molecular imprinting, Sol–gel, On-line solid-phase extraction, high-performance liquid chromatography


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