Authors: Prasad BB
, Srivastava S
, Tiwari K
, Sharma PS
Trace-level sensing of dopamine in real samples using molecularly imprinted polymer-sensor.
Publication date: 2009
Journal: Biochemical Engineering Journal
Alternative URL: http://www.sciencedirect.com/science/article/B6V5N-4V8GB9D-3/2/02a32bc204583d4e01be99b59635ad3d
Abstract: Induced-fit responsive dopamine (DA) imprinted polymer, poly (melamine-co-chloranil), was used as a suitable coating material for the modification of a hanging mercury drop electrode. The zwitterionic conformation of the imprinted polymer responded differential pulse, cathodic stripping voltammetric current, without any false-positive or false-negative contributions of non-specific sorptions, in aqueous environment of complex matrices. The limit of detection (3σ) of dopamine was found to be as low as 0.148ángámL-1, by the proposed sensor that could be considered a sensitive marker of dopamine depletion in Parkinson's disease (PD)
Template and target information: dopamine, DA
Author keywords: bioseparations, membrane, Mass-transfer, affinity, dopamine, molecularly imprinted polymer
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