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Reference type: Journal
Authors: Zaidi SA, Cheong WJ
Article Title: Preparation of an open-tubular capillary column with a monolithic layer of S-ketoprofen imprinted and 4-styrenesulfonic acid incorporated polymer and its enhanced chiral separation performance in capillary electrochromatography.
Publication date: 2009
Journal: Journal of Chromatography A
Volume: 1216
Issue: (14)
Page numbers: 2947-2952.
DOI: 10.1016/j.chroma.2008.08.015
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4T6M83H-B/2/cc509143f2457bef1f7497c379ebc374

Abstract: Enhanced chiral separation performance has been observed for ketoprofen enantiomers in capillary electrochromatography (CEC) with an open-tubular (OT) column prepared with a specific molecule imprinted polymer (MIP) on the innerwall of 50μm ID capillary. The column was prepared by in situ thermal polymerization inside the pretreated and silanized fused silica capillary. A specific diluted monomer mixture composed of S-ketoprofen, methacrylic acid (MAA, functional monomer), ethylene glycol dimethacrylate (EDMA, cross-linker), and 4-styrenesulfonic acid (4-SSA) dissolved in 9/1 (v/v) acetonitrile/2-propanol was used to fabricate the OT-MIP layer. 4-SSA was added to form a MIP layer capable of stable and strong electro-osmotic flow (EOF) over the pH range of this study securing CEC elution of ketoprofen having partial negative charge near the optimized pH. Various parameters such as buffer pH, organic modifier composition, salt concentration, and applied potential have been optimized for CEC chiral separation of ketoprofen enantiomers. Very good separation selectivity and efficiency were observed, thus the chromatographic resolution of ketoprofen enantiomers was as high as 10.5, and the number of theoretical plates of R-ketoprofen, 156,000/m (40,000/m for S-ketoprofen), which proves that the OT-MIP-CEC type approach is a promising strategy in MIP study
Template and target information: S-ketoprofen
Author keywords: capillary electrochromatography, chiral separation, ketoprofen, molecule imprinted polymer, Open-tubular capillary column, 4-Styrenesulfonic acid


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