Authors: Kempe M
, Mosbach K
Direct resolution of naproxen on a noncovalently molecularly imprinted chiral stationary-phase.
Publication date: 1994
Journal: Journal of Chromatography A
Abstract: A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen
Template and target information: (S)-naproxen
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