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Reference type: Journal
Authors: Tothill IE
Article Title: Biosensors for cancer markers diagnosis.
Publication date: 2009
Journal: Seminars in Cell & Developmental Biology
Volume: 20
Issue: (1)
Page numbers: 55-62.
DOI: 10.1016/j.semcdb.2009.01.015
Alternative URL: http://www.sciencedirect.com/science/article/B6WX0-4VJ0DSW-2/2/84df6ee2c5b28ae7a2bd4ba071ea2c23

Abstract: Point-of-care diagnostic devices present a viable option for the rapid and sensitive detection and analysis of cancer markers. With the growing number of cancer cases being diagnosed worldwide and the increased number of fatalities due to late disease detection, biosensors can play an important role in the early diagnosis of cancer. Molecular profiles of patients are being increasingly studied using new molecular tools such as genomic and proteomic techniques. These methods combined with bioinformatics tools are generating new data which is being employed in the elucidation of new disease biomarkers. As with many disease conditions finding specific and sensitive markers that are associated with only one type of the disease can be difficult. In addition to this, the level of the biomarkers in biological fluids can vary depending on different disease conditions and stages. A number of molecular markers are therefore usually evaluated for cancer diagnosis and these can include proteins, peptides, over/under expression of gene markers and gene mutations. This review provides an overview of the biosensor technology available today, areas which are currently being developed and researched for cancer markers diagnosis--and a consideration of future prospects for the technology
Template and target information: Review - Biosensors in cancer diagnosis
Author keywords: Cancer markers, Biosensors, nanomaterials, Diagnostics, Point-of-care devices

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