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Abstract: Flow injection chemiluminescence (FI-CL) with molecularly imprinted polymer (MIP) was applied to determine fenfluramine. The fenfluramine-imprinted polymer was prepared with acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. Methyl and sulfonic group were introduced to rhodanine matrix, and a novel rhodanine ramification 3MORASP was synthesized by the author, and it was used as chemiluminescence reagent. 3-(3'-Methoxyphenyl)-5(2'-sulfonylphenylazo)-rhodanine (3MORASP), first synthesized by the authors, was used as chemiluminescence (CL) reagent. The novel flow path of FI-CL was designed, which made three merged streams of reactants injected into MIP column move through different pathways simultaneously. Fenfluramine was detected based on the reaction of fenfluramine, 3MORASP, and potassium permanganate in an acidic medium. The CL intensity was correlated linearly with the concentration of fenfluramine over the range of 1.0 x 10^-7 to 5.0 x 10^-6 g mL^-1, and the detection limit was 9.48 x 10^-9 g mL^-1. The relative standard deviation (RSD) was 2.4% for determination of 1.0 x 10^-6g mL^-1 fenfluramine (n =11). This method was successfully applied to the determination of fenfluramine in weight-reducing tonic
Template and target information: fenfluramine
Author keywords: chemiluminescence, fenfluramine, flow injection, molecularly imprinted polymer (MIP), rhodanine