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Authors: Patel AK, Sharma PS, Prasad BB
Article Title: Voltammetric sensor for barbituric acid based on a sol-gel derivated molecularly imprinted polymer brush grafted to graphite electrode.
Publication date: 2009
Journal: International Journal of Pharmaceutics
Volume: 371
Issue: (1-2)
Page numbers: 47-55.
DOI: 10.1016/j.ijpharm.2008.12.016
Alternative URL: http://www.sciencedirect.com/science/article/B6T7W-4V74VCP-4/2/5bc6cd0f30d83bb8a33ff89354d109a9
Abstract: A voltammetric sensor based on a molecularly imprinted polymer (MIP) brush grafted to sol-gel film on graphite electrode is reported for the selective and sensitive analysis of barbituric acid (BA) in aqueous, blood plasma, and urine samples. The modified electrode was preanodised at +1.6áV (vs. saturated calomel electrode), where encapsulated BA involved hydrophobically induced hydrogen bondings, in MIP cavities exposed at the film/solution interface, at pH 7.0. Scanning electron microscopy (SEM) was employed to characterise the surface morphology of the resultant imprinted film of MIP brush. The differential pulse, cathodic stripping voltammetry (DPCSV) technique was employed to investigate the binding performance of the sol-gel-modified imprinted polymer brush, which yielded a linear response in the range of 4.95-100.00áμgámL-1 of BA with a detection limit of 1.6áμgámL-1 (S/Ná=á3)
Template and target information: barbituric acid, BA
Author keywords: Barbituric acid sensor, molecularly imprinted polymer, sol-gel, Graphite electrode, differential pulse, Cathodic stripping voltammetry
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