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Reference type: Journal
Authors: Duy SV, Lefebvre-Tournier I, Pichon V, Hugon-Chapuis F, Puy JY, Périgaud C
Article Title: Molecularly imprinted polymer for analysis of zidovudine and stavudine in human serum by liquid chromatography-mass spectrometry.
Publication date: 2009
Journal: Journal of Chromatography B
Volume: 877
Issue: (11-12)
Page numbers: 1101-1108.
DOI: 10.1016/j.jchromb.2009.02.068
Alternative URL: http://www.sciencedirect.com/science/article/B6X0P-4VS408M-2/2/c847be67d4cfc0d16ece35e48e521698

Abstract: A molecularly imprinted polymer (MIP) using zidovudine (AZT) as template and methacrylic acid as monomer was prepared. The synthesis of the MIP was performed in acetonitrile. The synthesized material was then tested for the solid-phase extraction of AZT from different media (pure organic solvents and hydro-organic mixtures). An optimised procedure was developed for the selective extraction of AZT with a recovery of 96% using the MIP and only 3% on a non-imprinted polymer used as control polymer. A specific capacity of 0.2áμmolág-1 was determined. The specificity of the MIP was evaluated by studying the retention behaviour of two others nucleoside analogues. The feasibility of the MIP to selectively extract AZT and stavudine (d4T) from human serum was also demonstrated with recoveries of 80 and 85% respectively. The lower limit of quantification (LLOQ) and the lower limits of detection (LLOD) for AZT were 5.10-7 and 10-7áM respectively
Template and target information: zidovudine, AZT, stavudine, d4T
Author keywords: molecularly imprinted polymer, Zidovudine, Stavudine, human serum, LC/ MS


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